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EXINT - Exon Intron
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Description
Genes in higher eukaryotes are often interrupted by intragenic non-coding sequences called introns. Thus, the gene structure is multi-exonic with multiple exons. The organization of introns in multi-exonic genes is seldom uniform and location, size, phase (conserved evolutionary character refers to the location of introns relative to the three nucleotide positions in triplet codon) of introns in the coding region is frequently random. Therefore, it is of critical importance to collect, systematically organize and store data points on eukaryotic gene structure in a relation manner. The ExIntTM database is a relation database on the world-wide-web (WWW) containing such information derived from GenBank. Hence, the availability of whole-genome sequences and search engines provides a magnificent laboratory for the investigation of genome evolution in eukaryota. The data and the database help to identify common evolutionary patterns in higher eukaryotic genes for the study of intron loss/gain, sliding, splicing, retroposition, recombination, intron/exon duplication, etc. As we also know that the locations of introns in homologous genes do not always coincide, this database can help us look into correlations of exons with the functional elements of protein gene products. The database provides multi-exon eukaryotic sequences in FASTA format with relevant gene structure information at the FASTA header. The database also provides options for specific searches through ‘key words’, LOCUS, NID, etc.
Please mail comments and queries to mmeena@ntu.edu.sg |
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