Human Single Exonic Genes

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Human Single exonic Genes

The human gene sequences are frequently interrupted by non coding, intragenic sequences called introns. The intervening introns gives the human genes a gene structure with multiple exons (coding region). Thus, human genes are predominantly intron-bearing and the gene structure is dissimilar to that of a bacterial gene structure.

However, a number of eukaryotic genes with a single exon were identified (Sakharkar et al. 2002). It is also found that many intron rich higher eukaryotes contain a sizeable amount of single exon genes (SEG) (Sakharkar et al. 2004). The current update of the human genome data contains about 12% SEG (Sakharkar et al. 2004). The presence of a considerable amount of SEG in the human genome is perplexing.

Therefore, the origin and function of human SEG is interesting. Thus, we assigned functions using a number of computational assignment techniques, namely, Pfam, Prosite, SUPERFAMILY and GenBank annotation.

Please mail comments and queries to mmeena@ntu.edu.sg