The MHC-Peptide Interaction Database (MHCP) is a curated MySQL database for sequence-structure-function information on MHC-Peptide interactions.  It contains all structures of Major Histocompability proteins containing bound peptides, with emphasis on the structural characterization of these complexes.

MHCP will facilitate the development of algorithms to predict whether a peptide sequence will bind to a specific MHC allele. The Database has been populated with the data from the Protein Data Bank (PDB). The Data from the PDB is manually verified and classified, after which each structure is analyzed for atomic interactions relevant to MHC-Peptide complex.

The MHCP database has been populated with the data from the Protein Data Bank (PDB). The data from the PDB is manually verified and classified, after which each structure is analyzed for atomic interactions relevant to MHC-Peptide complex. The intermolecular hydrogen bonds, Gap volume and Gap Index are pre-computed using the program SURFNET and the Interface area due to complex formation is calculated based on accessible surface area calculation performed by the NACCESS program.  Schematic diagrams of the MHC-Peptide interactions based on the plotting program LIGPLOT are also available. The Peptide consensus pattern available in MHCP are generated using the Program WEBLOGO.

MHCP contains 90 entries from three MHC sources (human:57,Murine:32 and Rat:1), spanning 21 alleles with 74 peptides. Class I MHC-Peptide complexes number 68 while 22 structures are from class II MHC. On the whole, 73 entries are non-redundant. (54 from class I and 19 from class II MHC-Peptide complexes. To view distribution graphically [click here].